Glutathione has been recognized by science as the most powerful of the antioxidants known to date, and represents the most important molecule for maintaining the health of our inner organism, the presence of which conditions the susceptibility of our natural defenses.

This small molecule is a determining element of the complex detoxifying, immune, antioxidant and even anti-inflammatory system of the human body.

Its function as an antioxidant leads it to be defined as a " Master antioxidant": it is essential not only as a powerful weapon of attack against excess free radicals, but it is also capable of regenerating other antioxidant substances, such as Vitamin C and Vitamin E, which once involved in the neutralization of radicals themselves become unstable radical molecules. Here Glutathione takes over this process, recycling and reactivating them, in order to make them functional for their neutralizing "scavenger" activity.

Glutathione, however, is essential for several other functions within our body, such as being our main detoxifying agent in neutralizing the toxic substances that accumulate and strongly supporting all our immune defense lines.

Unlike other antioxidants that come from food, glutathione is not found directly in food but is produced by the body especially in the liver and must be reassembled starting from cysteine, glycine and glutamine as the final product of the sulphation process.

This small molecule composed of three amino acids (glycine, cysteine, glutamate) acts as an enzyme or catalyst for various biochemical reactions, and this explains the presence of glutathione in all the cells and organs of our body. Furthermore, it is known that young organisms physiologically have more glutathione reserves than adults and that with aging these reserves are gradually depleted or reduced.

It is no coincidence that the quantity of glutathione is greater in the cells of detoxifying organs such as the liver, where it is particularly synthesized and whose action conditions greater control and elimination of excess toxins to which we are constantly exposed and which tend to accumulate in the body. 

However, the function that most identifies Glutathione is that antioxidant: it is in fact involved in a decisive way in the neutralization of reactive oxygen species (ROS or free radicals) and hydrogen peroxide. The formation of free radicals is a physiological process of every organism, but it can happen that their presence becomes excessive and potentially very harmful, favoring a pro "oxidative stress" condition.

Physiological levels of Glutathione will ensure better control over oxidative stress and the potential damage that free radicals can cause at the cellular level. But it doesn't end there. 

Glutathione also plays a fundamental role as a direct support to the immune defense against inflammation, infections, viruses, bacteria, etc. The activation of the immune system is favored by the increase in the production of glutathione by T lymphocytes and natural killer (NK) cells, which stimulates their energy metabolism also allowing them to grow, divide and effectively fight bacteria and viruses.

What happens when we have less Glutathione

Without sufficient presence of glutathione, T cells remain inactive and consequently we become weaker and more susceptible to various pathologies or to more rapid cellular aging. Unfortunately, there are several factors that can negatively affect the levels of glutathione in our body, starting from UV rays, alcohol, tobacco, emotional stress, lack of sleep, various drugs such as chemotherapy and antidepressants and above all paracetamol. 

These factors lead to an easier buildup of free radicals and accumulation of toxins, which the body copes with with its natural first line of defense of antioxidants, which often may not be sufficient.

From all this it clearly emerges that, with over 80,000 published studies demonstrating the central role of glutathione for health especially in old age, to promote detoxification processes and to strengthen our immune system we must somehow increase its production or enter it directly.

In this regard, until recently, glutathione could only be effectively taken by injection: the oral route has always been a strong limit for its absorption, so much so as to be practically discarded. Instead, a revolution has recently taken place, thanks to the arrival of new generation products such as Setria®, today's best-selling reduced glutathione on the world market. This form of Glutathione has in fact demonstrated its clinical effectiveness of absorption and accumulation also orally. With this patent, the multinational Japanese pharmaceutical company Kyowa Hakko Bio Co. Ltd, has succeeded in obtaining a completely purified form of glutathione from vegetable fermentation, the efficacy of which is finally supported by clinical research, overturning what was an established limit and exponentially extending the

Yamamoto in its Research and Nutrition lines, as a pioneering leader in the world of sports supplementation and nutraceuticals, always in contact with the best companies producing raw materials, immediately grasped the validity of this important innovation and introduced it catalog in the form of: Setribol®, GLR sublingale® and GLR stick®.

Glutathione supplementation in oral form proves to be a fundamental antioxidant, detoxifying and immune system support with a view to preventing various pathologies, with "slow aging" activity or health in general. This "master antioxidant" is in fact seen today as the true protagonist of our defense also in the form of an oral supplement (in particular the sublingual route, buccal stick, liposomal), accessible to all.

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